Max-Delbrueck-Center for molecular medicine

Prof. Dr. Jens Reich

Curriculum Vitae

General and Scientiffic Education
Sabbatical Periods Including Political Activity
Academic Degrees and Appointments
Scientific Awards
Selected List of Publications
Scientific Monographs
Belletristic and Political Monographs

Max Delbrück Center
PO Box 74023810
D-13092 Berlin

Tel. +49-30 / 9406 2833
Fax. +49-30 / 9406 2834

reich@mdc-berlin.de

General and Scientific Education, Professional Curriculum

1952: Abitur (high-school diploma) in Halberstadt, East Germany
1962: State diploma from Humboldt University, Berlin (Charité Medical Faculty)
1962 - 1964: general practitioner in Halberstadt
1964 - 1968: biochemical institute at medical faculty of Friedrich-Schiller Univeristy in Jena (Prof. Frunder)
1968 - 1991: research group leader (mathematical modelling of metabolism) at the Institute of Molecular Biology of the Academy of Sciences of East Germany
1992 - 2005: group leader (bioinformatics) at Max Delbrück Center
1998 - 2004: University Professor of Bioinformatics at Medical Faculty (Charité) of Humboldt University, Berlin

Sabbatical Periods Including Political Activity

From the early 80ies on, under the influence of reform groups in scientific and culture circles of the USSR, Poland and Czechoslovakia, I joined opposition groups striving for reform of the societal system of East Germany. This had reprecussions that inhibited my scientific work (dissolution of team, certain impediments). I found myself in a New Forum group that was instrumental in the 1989 political transformation and German unification, but resigned afterwards from political activity, in part by disappointment, in part because I wanted to save our team when MDC was founded after the end of East Germany. At present, my political engagement is confined to societal benefits and dangers of genome medicine, which I deem both relevant. I am trying to help moderating and focussing the rather emotional public debate in Germany.

1973/74: long-term stay at the Institute of Biophysics of the Academy of Sciences of the USSR in Pushchino on Oka (collaboration with Prof. Selkov)
1979/80: second long-term stay in Pushchino
1989/90: interruption of scientific career as co-founder of New Forum Political Movement, member of parlament until German unification in 1991
1991: Visiting professor at Harvard University, Center for European Studies
1992: Visiting professor at DKFZ Heidelberg (German Center of Cancer Research, work on sequence analysis and pertinent software
1994: Candidate for the Presidency of the Federal Republic of Germany
2001: Member of National Ethics Council of Germany

Academic Degrees and Appointments

1964: Degree of Dr. medicinae at Humboldt University
1976: Degree of Dr. med. sc. (equivalent to doctor habilitatus) at Academy of Science of East Germany
1979: Professor of Bioinformatics
1998 - 2004: Professor (C4) at Charité Medical Faculty of Humboldt University, Berlin

Scientific Awards

1976: Leibniz Medal of Academy of Sciences of East Germany
1983: Rudolf Virchow Award for Achievements in Medical Science
1991: Theodor-Heuss Award
1993: Anna-Krüger Literature Award
1996: Carl Gustav Carus Honorary Medal of the Society of German Naturalists and Physicians
2000: National Award of the Deutsche Nationalstiftung

Selected List of Publications

Reich, J.G.: Untersuchungen zur Entstehung arterieller Gefäßgeräusche. Med. Dissert. (1964) Med. Fakultät der Humboldt-Universität Berlin
Reich, J.G.: Analogue computer analysis of tracer flow patterns through the glycolytic and related pathways in erythrozytes and other intact metabolic systems. Eur. J. Biochem. 6 (1968) 245-251
Reich, J.G., Till, U., Günther, J., Zahn, D., Tschisgale, M. and Frunder, H.: Enzymic Flux rates in vivo through the Embden-Meyerhof-pathway and the nucleotides of mouse liver. Eur. J. Biochem. 6 (1968) 383-394
Till, U., Blume, E., Günther, J., Reich, J.G., Jarosziewicz, K. and Frunder, H.: Determination of specific radioactivities of mononucleotides and glycolytic intermediates from mouse liver after labelling in vivo with (hoch) 32p-orthophosphate. Eur. J. Biochem. 6 (1968) 373-383
Reich, J.G., Wangermann, G., Falck, M. and Rohde, K.: A general strategy for parameter estimation from isosteric and allosteric-kinetic data and binding measurements. Eur. J. Biochem. 11,26 (1972) 368-379
Reich, J.G., Drabsch, H. and Däumler, A.: On the statistical assessment of similarities in DNA-sequences. Nucleic Acids Research 12,13 (1984) 5529-5543
Reich, J.G.: On Optimum properties in the design of metabolic and epigenetic systems. Biomedica Biochimica Acta 44,6 (1985) 845-852
Reich, J.G. and Meiske, W.: Adaption games between microorganisms sharing a common substrate niche. J. of Basic Microbiology 25,8 (1985) 513-519
Reich, J.G. and Meiske, W.: A simple statistical significance test of window scores in large dot matrices obtained from protein or nucleic-acid sequences. Computer Applications in the Biosciences 3,1 (1987) 25-30
Bauer, D., Müller, H., Reich, J., Riedel, H., Ahrenkiel, V., Warthoe, P. and Strauss, M.: Identification of differentially expressed mRNA species by an improved display technique (DDRT-PCR). Nucleic Acids Res. 21 (1993) 4272-4280
Hanke,J., Beckmann, G., Bork, P. and Reich, J.: Self-organizing hierarchic networks for pattern recognition in protein sequence. Protein Sci. 5 (1996) 72-82
Hanke,J. and Reich, J.: Kohonen map as visualization tool for the analysis of protein sequences: multiple alignments, domains and segments of secondary structures. CABIOS 12 (1996) 447-454
Strohner, P., Sarrach, D. and Reich, J.G.: Use of a modified binding model for the investigation of affinity dependence on antibody concentration in immunoassay systems. J. Immunol. Methods 203 (1997) 113-122
Beckmann, G., Hanke, J., Bork, P. and Reich, J.: Merging extracellular domains: Fold prediction for laminin G-like and aminoterminal thrombospondin-like modules based on homology to pentraxins. J. Mol. Biol. 275 (1998) 725-730
Lucek, P., Hanke, J., Reich, J., Solla, S.A. and Ott, J.: Multi-Locus Nonparametric Linkage Analysis of Complex Trait Loci Neural Networks. Human Heredity 48 (1998) 275-284
Hanke, J., Brett, D., Zastrow, I., Aydin, A., Delbrück, S., Lehmann, G., Luft, F., Reich, J.G. and Bork, P.: Alternative splicing of human genes more the rule than the exception? Trends Genet. 15,10 (1999) 389-390
Hanke, J., Lehmann, G., Bork, P. and Reich, J.G.:Associative database of protein sequences. Bioinformatics 15,9 (1999) 741-748
Reich, J.G.: View from the East. Science 286 (1999) 1087-1087
Sunyaev, S., Hanke, J., Aydin, A., Wirkner, U., Zastrow, I. and Reich, J.G.: Prediction of nonsynonymous single nucleotide polymorphisms in hu disease-associated genes. J. Mol. Med. 77 (1999) 754-760
Brett, D., Hanke, J., Lehmann, G., Haase, S., Delbrück, S., Krueger, S., Reich, J. and Bork, P.: EST comparison indicates 38% of human mRNAs contain possible alternative splice forms. Febs Lett. 474 (2000) 83-86
Brett, D., Lehmann, G., Hanke, J., Bork, P. and Reich, J.G.. EST analysis online: WWW tools for the detection of SNPs and alternative splice forms. Trends in Genetics 16, 9 (2000) 416-418
Knoblauch, H., Schuster, H., Luft, J. C. and Reich, J.: A pathway model of lipid metabolism to predict the effect of genetic variability on lipid levels. J. Mol. Med. 78(2000) 507-515
Li, W. T. and Reich, J.: A complete enumeration and classification of two-locus disease models. Hum. Hered. 50(2000) 334-349
Sunyaev, S., Hanke, J., Brett, D., Aydin, A., Zastrow, I., Lathe, W., Bork, P. and Reich, J.G.: Individual variation in protein-coding sequences of human genome. Adv. Prot. Chem. 54 (2000) 409-437
Brett, D., Pospisil, H., Valcárcel, J., Reich, J. and Bork, P.: Alternative splicing and genome complexity. Nature Genetics 30 (2002) 29-30
Knoblauch, H., Bauerfeind, A., Krähenbühl, C., Daury, A., Rohde, K., Bejanin, S., Essioux, L., Schuster, H., Luft, F. C. and Reich, J.G.: Common haplotypes in five genes influence genetic variance of LDL and HDL cholesterol in the general population. Hum. Mol. Genetics 11, 12 (2002) 1477-1485
Bauerfeind, A., Knoblauch, H., Schuster, H., Luft, F. C. and Reich, J. G.: Single nucleotide polymorphism haplotypes in the cholesteryl-ester transfer protein (CETP) gene and lipid phenotypes. Hum.Hered. 54 (2002) 166-173
Reich, J.G.: Embryonic stem cells - The Debate in Germany. Science 296 (2002) 265
Pospisil, H., Herrmann, A., Pankow, H. and Reich, J.: A database on alternative splice forms on the Integrated Genetic Map Service (IGMS). In silico biology 3 (2003) 229-234
Knoblauch, H., Bauerfeind, A., Toliat, M. R., Becker, C., Luganskaja, T., Gnther, U. P., Rohde, K., Schuster, H., Junghans, C., Luft, F. C., Nrnberg, P. and Reich, J.G.: Haplotypes and SNPs in 13 lipid-relevant genes explain most of the genetic variance in high-density lipoprotein and low-density lipoprotein cholesterol. Hum. Mol. Genetics 13, 10 (2004) 993-1004
Pospisil, H., Herrmann, A., Bortfeldt, R. H. and Reich, J.G.: EASED: Extended alternatively spliced EST database. Nucleic Acids Res. 32 (2004) D70-D74
Reich, J.: Empirische Totipotenz und methaphysische Gattungszugehörigkeit bei der moralischen Beurteilung des vorgeburtlichen menschlichen Lebens. Zeitschrift für Medizinische Ethik 50 (2004) 115-130

Scientific Monographs (including contributions)

Reich, J.G. and Selkov, E.E. : Energy Metabolism of the Cell. A Theoretical Treatise. Academic Press, London, 1981
Reich, J.G.: On parameter redundancy in curve fitting of kinetic data. In: "Kinetic data analysis." Endrenyi, L. ed., pp.39-50. Plenum Press, New York and London, 1981
Reich, J.G.: Curve Fitting on the Personal Computer. Mc Graw Hill, New York, 1992
Reich, J.G.: Es wird ein Mensch gemacht. Möglichkeiten und Grenzen der Gentechnik. Rowohlt-Verlag, Berlin, 2003

Belletristic and Political Monographs

»Rückkehr nach Europa. Zur Lage der deutschen Nation« (Hanser Verlag, München 1991) also dtv Sachbuch 1992
»Abschied von den Lebenslügen. Die Intelligenz und die Macht« (Rowohlt Berlin, 1992)
»Jens Reich im Gespräch mit Mathias Greffrath und Konrad Adam« (Hanser Verlag, München, 1994)
»Spiel, Raum, Sprache« (Wallstein-Verlag, Göttingen, 1998)
»Liebling, Du hast die Katze geklont!: Biotechnologie im Alltag« (Wiley-VCH Verlag GmbH, Weinheim, 2004)

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