Alternative Splicing
Haplotype Estimation
Entropy-LD
HNB
GandrKB

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04/26/2007:Please notice, that the IGMS system was shutdown at the end of april and will not coming back!

• Alternative Splicing
  Search the EST database for alternative splice forms in a query mRNA or protein.
• Haplotype Estimation
  Prediction of haplotype frequencies via the Maximum Likelihood algorithm. Genetic data of core families or independent probands can be uploaded for analysis.
• Multilocus LD calculation
  Calculation of linkage disequilibrium (LD) values for haplotypes using an entropy-based multilocus LD measure. The haplotypes and their frequencies can either be uploaded into a web-based calculator or the ANSI-C sources for a stand-alone program can be downloaded for repeated use.
• Simulation of SNP sequences
  Simulation of haplotypic and genotypic data of single nucleotide polymorphisms (SNP) in haplotype blocks, with an optional genotype-dependent assignment of a phenotype (affection status or quantitative trait).
• Webbased GandrKB (Gene annotation data representation)
  An ontology and knowledgebase describing gene functions enabeling biologists to annotate (multiple) genes on Affymetrix Microarrays per simple /drag and drop/. Annotation-concepts and genes can be linked for fast and intuitive context-exploration and extensive querying. Generated gene annotations can be interactively explored as semantic networks with advanced visualisation tools.
• HNB
  Helmholtz Network for Bioinformatics.
• Comparative Sequence Analysis
  Exploitation of evolutionary information that is traceable in biological sequence data. (Peer Bork).